Scientific research on cellular nutrients in fighting cancer

Clinical studies on cellular nutrients

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance.
Br J Cancer 1982 Sep;46(3):354-67
Anthony HM; Schorah CJ

Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of the consumption of food with an elevated content of this vitamin
Nutr Hosp 1995 Nov-Dec;10(6):368-72
Nunez Martin C ; Ortiz de Apodaca y Ruiz A
Servicio de Bioquimica, Hospital Virgen de la Salud, Toledo, Espana.

Endogenous urinary 3-hydroxyproline has 96% specificity and 44% sensitivity for cancer screening.
J Lab Clin Med 1992 Dec;120(6):908-20
Okazaki I ; Matsuyama S ; Suzuki F; Maruyama K; Maruta A; Kubochi K; Yoshino K; Kobayashi Y; Abe O; Tsuchiya M
Department of Preventive Medicine, School of Medicine, Keio University, Tokyo, Japan

Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract.
Eur J Clin Nutr 2001 Apr;55(4):293-7
Federico A; Iodice P; Federico P; Del Rio A; Mellone MC; Catalano G; Federico P
Semeiotics and Clinical Methodology, II University of Naples, Naples, Italy.

The relationship of dietary selenium and breast cancer.
J Surg Oncol 1980;15(1):67-70
McConnell KP; Jager RM; Bland KI ; Blotcky AJ

Reduction of cancer mortality and incidence by selenium supplementation.
Med Klin (Munich) 1997 Sep 15;92 Suppl 3:42-5
Combs GF; Clark LC; Turnbull BW

Research data on cellular nutrients

Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China.
Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK, Yu MC.
USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. canlan@hsc.usc.edu

Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden
Int J Cancer 2000 Jul 1;87(1):133-40
Ekstrom AM; Serafini M; Nyren O; Hansson LE; Ye W; Wolk A
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden

Dietary carotenoids and vitamins A, C, and E and risk of breast cancer.
J Natl Cancer Inst 1999 Mar 17;91(6):547-56
C Zhang S; Hunter DJ; Forman MR; Rosner BA; Speizer FE; Colditz GA; Manson JE; Hankinson SE; Willett WC
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. Shumin.Zhang@channing.harvard.edu .

A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review.
Cancer Detect Prev 2000;24(1):91-9
Fujiki H; Suganuma M; Okabe S; Sueoka E; Suga K; Imai K; Nakachi K
Saitama Cancer Center Research Institute, Kitaadachi-gun, Japan.

Two stages of cancer prevention with green tea.
J Cancer Res Clin Oncol 1999 Nov;125(11):589-97 Combs GF; Clark LC; Turnbull BW

Cancer inhibition by green tea.
Mutat Res 1998 Jun 18;402(1-2):307-10
Fujiki H; Suganuma M; Okabe S; Sueoka N; Komori A; Sueoka E; Kozu T; Tada Y; Suga K; Imai K; Nakachi K
Saitama Cancer Center Research Institute, Ina, Kitaadachi-gun, Saitama 362, Japan

Influence of drinking green tea on breast cancer malignancy among Japanese patients.
Jpn J Cancer Res 1998 Mar;89(3):254-61
Nakachi K; Suemasu K; Suga K; Takeo T ; Imai K; Higashi Y
Department of Epidemiology, Saitama Cancer Center Research Institute.

L-arginine stimulates host defenses in patients with breast cancer.
Surgery 1994 Feb;115(2):205-12
Brittenden J; Park KG; Heys SD; Ross C; Ashby J; Ah-See A; Eremin O
Department of Surgery, University of Aberdeen Medical School, Scotland.

A population-based case-control study of carotenoid and vitamin A intake and ovarian cancer (United States).
Cancer Causes Control 2001 Jan;12(1):83-90
Bertone ER; Hankinson SE; Newcomb PA; Rosner B; Willet WC; Stampfer MJ; Egan KM
Department of Boistatistics and Epidemiology, University of Massachusetts, Amherst 01003-9304, USA. elizabeth.bertone@channing.harvard.edu .

Megadose vitamins in bladder cancer: a double-blind clinical trial.
J Urol 1994 Jan;151(1):21-6
Lamm DL; Riggs DR; Shriver JS; van Gilder PF; Rach JF; De Haven JI
Department of Urology, West Virginia University School of Medicine, Morgantown.

Biochemical changes in the connective tissue components of malignant tumors and lungs in mice during metastatic spreading and chemotherapy
Vopr Med Khim 1989 Sep-Oct;35(5):30-4
Chubinskaia SG; Sevast'ianova NA; Veksler IG; Slutskii LI

Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines.
Anticancer Res 1998 Jul-Aug;18(4A):2487-93
Koh WS; Lee SJ; Lee H; Park C; Park MH; Kim WS; Yoon SS; Park K; Hong SI; Chung MH; Park CH
Department of Medicine, Samsung Medical Center, Kangnam-ku Seoul, Korea.

Tea polyphenols: prevention of cancer and optimizing health
Am J Clin Nutr 2000 Jun;71(6 Suppl):1698S-702S; discussion 1703S-4S
Mukhtar H; Ahmad N
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA. hxm4@po.cwru.edu .

Activation mechanisms of matrix metalloproteinases.
Biol Chem 1997 Mar-Apr;378(3-4):151-60
Nagase H
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160, USA.

Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines.
Anticancer Drugs 1996 Jun;7(4):461-8
Valcic S ; Timmermann BN; Alberts DS; Wachter GA; Krutzsch M; Wymer J; Guillen JM
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721, USA.

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols.
Carcinogenesis 1998 Apr;19(4):611-6
Yang GY; Liao J; Kim K; Yurkow EJ; Yang CS
Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789, USA.

Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.
Carcinogenesis 2003 Aug;24(8):1369-78
Chen C; Shen G; Hebbar V; Hu R; Owuor ED; Kong AN
Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells.
J Cell Biochem 1997 Oct 1;67(1):55-65
Liang YC; Lin-shiau SY; Chen CF; Lin JK
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Republic of China.

Matrix metalloproteinase inhibition by green tea catechins.
Biochim Biophys Acta 2000 Mar 16;1478(1):51-60
Demeule M; Brossard M; Page M; Gingras D; Beliveau R
Laboratoire de Medecine Moleculaire, Hopital Sainte-Justine - UQAM, C.P. 8888, Succursale centre-ville, Montreal, QC, Canada.

Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.
J Natl Cancer Inst 1997 Dec 17;89(24):1881-6
Ahmad N; Feyes DK; Nieminen AL; Agarwal R; Mukhtar H
Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Anti-metastatic effect of an autooxidation-resistant and lipophilic ascorbic acid derivative through inhibition of tumor invasion
Anticancer Res 2000 Jan-Feb;20(1A):113-8
Liu JW; Nagao N; Kageyama K; Miwa N
Department of Cell Biochemistry, Hiroshima Prefectural University School of BioSciences, Japan.

Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives.
Cancer Lett 1998 Jan 9;122(1-2):93-9
Roomi MW; House D; Eckert-Maksic M; Maksic ZB; Tsao CS
Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306, USA

Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro.
Cancer Lett 1996 Jun 5;103(2):183-9
Kurbacher CM; Wagner U; Kolster B; Andreotti PE; Krebs D; Bruckner HW
Department of Gynecology and Obstetrics, University of Bonn Medical Center, Germany

Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake.
Mol Carcinog 1999 Dec;26(4):213-25
Jiang C; Jiang W; Ip C; Ganther H; Lu J
Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado 80214, USA.

Inhibition of aminopeptidase N (AP-N) and urokinase-type plasminogen activator (uPA) by zinc suppresses the invasion activity in human urological cancer cells.
Biol Pharm Bull 2001 Mar;24(3):226-30
Ishii K; Usui S; Sugimura Y; Yamamoto H; Yoshikawa K; Hirano K
Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Japan.

Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer.
Prostate 1998 Jun 1;35(4):285-96
Costello LC; Franklin RB
OCBS/Cellular and Molecular Biology Section, Dental School, University of Maryland Health Sciences Center, Baltimore 21201, USA. lcostell@umaryland.edu .

Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.
J Natl Cancer Inst 2001 Oct 17;93(20):1525-33
Fong LY; Nguyen VT; Farber JL
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107-6799, USA. L_Fong@lac.jci.tju.edu .

Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines.
J Endocrinol 2001 May;169(2):417-24
Iitaka M; Kakinuma S; Fujimaki S; Oosuga I; Fujita T; Yamanaka K; Wada S; Katayama S
Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan.

Effect of zinc on immune functions and host resistance against infection and tumor challenge.
Immunopharmacol Immunotoxicol 1992;14(4):813-40
Singh KP; Zaidi SI; Raisuddin S; Saxena AK; Murthy RC; Ray PK
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India

Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
Clin Cancer Res 2002 Nov;8(11):3579-83
Uzzo RG; Leavis P; Hatch W; Gabai VL; Dulin N; Zvartau N; Kolenko VM
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat.
J Natl Cancer Inst 1980 Dec;65(6):1299-301
Thompson HJ; Becci PJ

Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate.
Biochem Biophys Res Commun 2000 Aug 28;275(2):328-34
Ahmad N; Gupta S ; Mukhtar H
Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.

Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells.
Arch Biochem Biophys 2000 Apr 15;376(2):338-46 Ahmad N; Gupta S ; Mukhtar H
Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.

Green Tea Constituent (-)-Epigallocatechin-3-Gallate Inhibits Hep G2 Cell Proliferation and Induces Apoptosis through p53-Dependent and Fas-Mediated Pathways [In Process Citation]
J Biomed Sci 2003 Mar-Apr;10(2):219-27
Kuo PL; Lin CC
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.

Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallate.
Arch Biochem Biophys 2002 Feb 1;398(1):125-31
Ahmad N; Adhami VM; Gupta S ; Cheng P; Mukhtar H
Department of Dermatology, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.

Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate.
Cancer Lett 1998 Aug 14;130(1-2):1-7
Paschka AG; Butler R; Young CY
Department of Urology, Mayo Clinic/Foundation, Rochester, MN 55905, USA.

Induction of apoptosis by the green tea flavonol (-)-epigallocatechin-3-gallate in human endothelial ECV 304 cells.
Anticancer Res 2002 Nov-Dec;22(6A):3373-8 Yoo HG; Shin BA; Park JC; Kim HS; Kim WJ; Chay KO; Ahn BW; Park RK; Ellis LM; Jung YD
Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea.

Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture.
J Cell Biochem 2001;82(3):387-98
Kavanagh KT; Hafer LJ; Kim DW; Mann KK; Sherr DH; Rogers AE; Sonenshein GE
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade.
Biochem Pharmacol 1999 Sep 15;58(6):911-5 Lin JK; Liang YC; Lin-Shiau SY
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei.

Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines.
Clin Cancer Res 2001 Dec;7(12):4220-9
Masuda M; Suzui M; Weinstein IB
Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032-2704, USA.

Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.
Anticancer Res 2003 Mar-Apr;23(2B):1533-9
Hsu S ; Lewis J; Singh B; Schoenlein P; Osaki T; Athar M; Porter AG; Schuster G
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry , AD1443. Medical College of Georgia, Augusta, GA 30912-1126, USA. shsu@mail.mcg.edu .

Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells.
Biochem Biophys Res Commun 2000 Apr 21;270(3):793-7
Islam S ; Islam N; Kermode T; Johnstone B; Mukhtar H; Moskowitz RW; Goldberg VM; Malemud CJ; Haqqi TM
Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland Ohio 44106, USA.

Epigallocatechin gallate protects U937 cells against nitric oxide-induced cell cycle arrest and apoptosis.
J Cell Biochem 2001;81(4):647-58
Kelly MR; Geigerman CM; Loo G
Cellular and Molecular Nutrition Research Laboratory, Graduate Program in Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402-6170, USA.

Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells.
Redox Rep 2002;7(3):171-7
Nie G; Cao Y; Zhao B
Laboratory of Visual Information Processing, Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, 15 Datun Road, Chaoyang District, Beijing 100101, P.R. China.

(-)-Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: inhibitory effects against biochemical events and tumor initiation in Sencar mouse skin.
Prostate 2001 Feb 1;46(2):98-107
Katiyar SK; Agarwal R; Wang ZY; Bhatia AK; Mukhtar H
Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, OH.

Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells.
Cancer Lett 1998 Aug 14;130(1-2):1-7
Bhatia N; Agarwal R
Center for Cancer Causation and Prevention, AMC Cancer Research Center, 1600 Pierce Street, Denver, CO 80214, USA.

Green tea and its catechins inhibit breast cancer xenografts.
Nutr Cancer 2001;40(2):149-56
Sartippour MR; Heber D; Ma J; Lu Q; Go VL; Nguyen M
Department of Surgery, University of California, Los Angeles, CA 90095, USA.
A.

(-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice.
Carcinogenesis 2000 May;21(5):915-9
Mimoto J; Kiura K; Matsuo K; Yoshino T; Takata I; Ueoka H; Kataoka M; Harada M
Second Department of Medicine, Second Department of Pathology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan

(-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts.
Breast Cancer Res Treat 2002 Dec;76(3):195-201
Vergote D; Cren-Olive C; Chopin V; Toillon RA; Rolando C; Hondermarck H; Le Bourhis X
Laboratoire de Biologic du Developpement (UPRES-EA 1033), Universite des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.

Gene expression profile in human prostate LNCaP cancer cells by (--) epigallocatechin-3-gallate.
Cancer Lett 2002 Aug 8;182(1):43-51
Wang SI; Mukhtar H
Dermatology Department, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028, USA.

Green tea and prostate cancer.
Urol Clin North Am 2002 Feb;29(1):49-57, viii
Gupta S; Mukhtar H
Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).
Mol Biol Cell 1999 Apr;10(4):1093-104
Ahn HY; Hadizadeh KR; Seul C; Yun YP; Vetter H; Sachinidis A
Department of Pharmacology, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.

Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells.
Sazuka M; Murakami S; Isemura M; Satoh K; Nukiwa T
School of Food and Nutritional Sciences, University of Shizuoka, Japan.

Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea.
Int J Exp Pathol 2001 Dec;82(6):309-16
Jung YD; Ellis LM
Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea.

Novel approaches to chemoprevention of skin cancer.
J Dermatol. 2000 Nov;27(11):691-5.
Bickers DR, Athar M.
Department of Dermatology, Columbia Medical Center, 161 Fort Washington Avenue, New York, NY 10032, USA.

Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability, and DNA synthesis.
Prostate 1997 Aug 1;32(3):188-95
Maramag C; Menon M; Balaji KC; Reddy PG; Laxmanan S
Division of Urologic and Transplantation Surgery, University of Massachusetts Medical Center, Worcester 01655, USA.

Effect of vitamin C on androgen independent prostate cancer cells (PC3 and Mat-Ly-Lu) in vitro: involvement of reactive oxygen species-effect on cell number, viability and DNA synthesis.
Cancer Biochem Biophys 1998 Jun;16(1-2):17-30
Menon M; Maramag C; Malhotra RK; Seethalakshmi L
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA.

Combined vitamins B12b and C induce the glutathione depletion and the death of epidermoid human larynx carcinoma cells HEp-2.
Biosci Rep 2000 Oct;20(5):411-7
Akatov VS; Evtodienko YV; Leshchenko VV; Teplova VV; Potselueva MM; Kruglov AG; Lezhnev EI; Yakubovskaya RI
Laboratory of Cytotechnology, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region. akatov@venus.iteb.serpukhov.su .

Antimetastatic and anti-invasive ability of phospho-ascorbyl palmitate through intracellular ascorbate enrichment and the resultant antioxidant action
Oncol Res 1999;11(10):479-87
Liu JW; Nagao N; Kageyama K; Miwa N
Department of Cell Biochemistry, Hiroshima Prefectural University School of BioSciences, Shobara, Japan.

Inhibitory effect of dietary arginine on growth of Ehrlich ascites tumor cells in mice.
J Nutr 1979 Mar;109(3):489-94
Milner JA; Stepanovich LV

Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats.
Biofactors 2001;15(1):11-26
Davis CD; Johnson WT
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA. cdavis@gfhnrc.ars.usda.gov .

A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression.
DNA Cell Biol 2003 Mar;22(3):217-24
Ahn WS; Huh SW; Bae SM; Lee IP; Lee JM; Namkoong SE; Kim CK; Sin JI
Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro.
Anticancer Res 2000 Sep- Oct;20(5B):3459-65
Elattar TM; Virji AS
Hormone Research Laboratory, University of Missouri-Kansas City, School of Dentistry and Medicine, Kansas City, MO 64108, USA.

Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells.
Oncogene 2003 Jul 31;22(31):4851-9
Hastak K; Gupta S ; Ahmad N; Agarwal MK; Agarwal ML; Mukhtar H
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells.
Arch Biochem Biophys 2003 Feb 1;410(1):177-85
Gupta S ; Hussain T ; Mukhtar H
Department of Urology, Jim & Eillen Dicke Research Laboratory, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106, USA

Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols.
Jpn J Cancer Res 1997 Jul;88(7):639-43
Okabe S ; Suganuma M; Hayashi M; Sueoka E; Komori A; Fujiki H
Saitama Cancer Center Research Institute.

Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate.
J Urol 2003 Sep;170(3):773-6
Kemberling JK; Hampton JA; Keck RW; Gomez MA; Selman SH
Department of Urology, Medical College of Ohio, 3065 Arlington Avenue, Dowling Hall 2170, Toledo, OH 43614-5807, USA.

Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.
Cancer Res 2003 Feb 15;63(4):824-30
Naasani I ; Oh-Hashi F; Oh-Hara T ; Feng WY; Johnston J; Chan K; Tsuruo T
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan. inaasani@biocrystal.com .

Chemoprevention of oral cancer by green tea.
Gen Dent 2002 Mar-Apr;50(2):140-6
Hsu SD; Singh BB; Lewis JB; Borke JL; Dickinson DP; Drake L; Caughman GB; Schuster GS
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, USA.

Green tea and cancer chemoprevention.
Mutat Res 1999 Jul 16;428(1-2):339-44
Suganuma M; Okabe S ; Sueoka N; Sueoka E; Matsuyama S ; Imai K; Nakachi K; Fujiki H
Saitama Cancer Center Research Institute, Ina, Kitaadachi-gun, Saitama 362-0806, Japan

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate.
Cancer Lett 1995 Sep 25;96(2):239-43
Liao S ; Umekita Y; Guo J; Kokontis JM; Hiipakka RA
Ben May Institute, Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA.

Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/HeNCrj mice and human hepatoma-derived PLC/PRF/5 cells.
Jpn J Cancer Res 1994 Mar;85(3):221-5
Nishida H; Omori M; Fukutomi Y; Ninomiya M; Nishiwaki S ; Suganuma M; Moriwaki H; Muto Y
First Department of Internal Medicine, Gifu University School of Medicine.

Anticarcinogenic activity of green tea polyphenols. .
Jpn J Clin Oncol 1993 Jun;23(3):186-90
Komori A; Yatsunami J; Okabe S ; Abe S ; Hara K; Suganuma M; Kim SJ; Fujiki H
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo.

Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives. Cancer Res 1992 Jul 1;52(13):3582-8
R; Katiyar SK; Zaidi SI; Mukhtar H
Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Ohio.

Progress in studies on the antimutagenicity and anticarcinogenicity of green tea epicatechi
Chin Med Sci J 1991 Dec;6(4):233-8
Cheng S ; Ding L; Zhen Y; Lin P; Zhu Y; Chen Y; Hu X
Institute of Oncology, CAMS, Beijing.

Molecular targets for green tea in prostate cancer prevention.
J Nutr 2003 Jul;133(7 Suppl):2417S-2424S
Adhami VM; Ahmad N; Mukhtar H
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA

Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.
Pancreas 2002 Jul;25(1):45-8
Takada M; Nakamura Y; Koizumi T ; Toyama H; Kamigaki T ; Suzuki Y; Takeyama Y; Kuroda Y
First Department of Surgery, Kobe University School of Medicine, Kobe, Japan. moriatsu@med.kobe-u.ac.jp .

Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1.
Int J Oncol 2002 Jun;20(6):1233-9
Fujimoto N; Sueoka N; Sueoka E; Okabe S ; Suganuma M; Harada M; Fujiki H
Saitama Cancer Center, Ina, Kitaadachi-gun 362-0806, Japan.

Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro.
Chem Biol Interact 1998 Apr 3;110(3):159-72 Kennedy DO; Nishimura S; Hasuma T; Yano Y; Otani S; Matsui-Yuasa I
Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Osaka, Japan.

Potent inhibitory action of red wine polyphenols on human breast cancer cells.
J Cell Biochem 2000 Jun 6;78(3):429-41
Damianaki A; Bakogeorgou E; Kampa M; Notas G; Hatzoglou A; Panagiotou S; Gemetzi C; Kouroumalis E; Martin PM; Castanas E
Laboratory of Experimental Endocrinology, University of Crete, School of Medicine and University Hospital, Heraklion, Greece.

Green tea: cancer preventive beverage and/or drug.
Cancer Lett 2002 Dec 15;188(1-2):9-13
Fujiki H; Suganuma M; Imai K; Nakachi K
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, 770-8514, Tokushima, Japan. hfujiki@ph.bunri-u.ac.jp

Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells.
Cancer Res 2002 Feb 1;62(3):652-5
Pianetti S; Guo S; Kavanagh KT; Sonenshein GE
Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118-2394, USA.

Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer.
Altern Med Rev 1999 Oct;4(5):360-70
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Sage Health Clinic, Bend, OR, USA. drcowboyup@hotmail.com .

Growth inhibition of leukemic cells by (-)-epigallocatechin gallate, the main constituent of green tea
Life Sci 1998;63(16):1397-403
Otsuka T; Ogo T; Eto T; Asano Y; Suganuma M; Niho Y
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expression
Anticancer Res 2001 Nov-Dec;21(6A):3743-8
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Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta 30912-1126, USA. shsu@mail.mcg.edu .

Inhibitory effect of green tea extract on the process of pancreatic carcinogenesis induced by N-nitrosobis-(2-oxypropyl)amine (BOP) and on tumor promotion after transplantation of N-nitrosobis-(2-hydroxypropyl)amine (BHP)-induced pancreatic cancer in Syrian hamsters
Cancer Res 2002 Feb 1;62(3):652-5
Pianetti S; Guo S; Kavanagh KT; Sonenshein GE
Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118-2394, USA.

Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins
Biosci Biotechnol Biochem 1997 Sep;61(9):1504-6
Sazuka M; Imazawa H; Shoji Y; Mita T ; Hara Y; Isemura M
School of Food and Nutritional Sciences, University of Shizuoka, Japan.

Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate
Cancer 2001 Feb 15;91(4):822-32
Garbisa S; Sartor L; Biggin S; Salvato B ; Benelli R; Albini A
Department of Experimental Biomedical Sciences, Medical School, University of Padova, viale G. Colombo 3, 35121 Padova, Italy. garbisa@civ.bio.unipd.it .

Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin)
J Biochem (Tokyo) 2003 May;133(5):571-6
Oneda H; Shiihara M; Inouye K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502.

Tea catechins and related polyphenols as anti-cancer agents
Biofactors 2000;13(1-4):81-5
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Laboratory of Cellular Biochemistry, Graduate School of Nutritional and Environmental Sciences, The University of Shizuoka, Japan.

Inhibition of fibroblast growth factors by green tea
Int J Oncol 2002 Sep;21(3):487-91
Sartippour MR; Heber D; Zhang L; Beatty P; Elashoff D; Elashoff R; Go VL; Brooks MN
Department of Surgery, Division of Oncology, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production
Nutr Cancer 2001;41(1-2):119-25
Tang FY; Meydani M
Vascular Biology Laboratory, JM USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients
Jpn J Cancer Res 2000 Jan;91(1):34-40
Li HC; Yashiki S; Sonoda J; Lou H; Ghosh SK; Byrnes JJ; Lema C; Fujiyoshi T; Karasuyama M; Sonoda S
Department of Virology, Faculty of Medicine, Kagoshima University, Sakuragaoka.

The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG).
Amino Acids 2002;22(2):131-43
Wang YC; Bachrach U
Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX)
Pharmacol Toxicol 2003 May;92(5):234-41
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Anticarcinogenic effects of (-)-epigallocatechin gallate.
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Fujiki H; Yoshizawa S ; Horiuchi T ; Suganuma M; Yatsunami J; Nishiwaki S ; Okabe S ; Nishiwaki-Matsushima R; Okuda T ; Sugimura T
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan

Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines.
Jpn J Cancer Res 1999 Jul;90(7):733-9
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Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds.
Cancer Lett 1995 Aug 16;95(1-2):221-5
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Amala Cancer Research Centre, Thrissur, Kerala, India.

Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents.
Biochem Pharmacol 2000 Oct 15;60(8):1051-9 Agarwal R
Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, CO 80214, USA. agarwalr@amc.org .

Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells.
J Agric Food Chem 2003 Mar 26;51(7):1858-63 Maeda-Yamamoto M; Suzuki N; Sawai Y; Miyase T ; Sano M; Hashimoto-Ohta A; Isemura M
National Institute of Vegetable and Tea Science, NARO, 2769 Kanaya, Shizuoka 428-8501, Japan. marimy@affrc.go.jp .

Inhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea.
Int J Urol 1999 Feb;6(2):93-9
Sato D
Second Department of Urology, Toho University of Medicine, Tokyo, Japan.

Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Jpn J Cancer Res 1996 Oct;87(10):1034-8
Matsumoto N; Kohri T ; Okushio K; Hara Y
Food Research Laboratories, Mitsui Norin Co., Ltd., Shizuoka, Japan.

Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.
Breast Cancer Res Treat 1994;30(3):233-42
Bhide SV; Azuine MA; Lahiri M; Telang NT
Carcinogenesis Division, Cancer Research Institute, Bombay, India.

Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.
Oncogene 2000 Apr 6;19(15):1924-32
Ren F; Zhang S ; Mitchell SH; Butler R; Young CY
Department of Urology, Mayo Graduate School, Mayo Foundation, Rochester, Minnesota, MN 55905, USA.

Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas.
Nutr Cancer 2000;38(2):265-73
Zhang G; Miura Y; Yagasaki K
Department of Applied Biological Science, Tokyo Noko University, Japan.

Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells.
Biochim Biophys Acta 2002 Jan 30;1542(1-3):209-20
Annabi B ; Lachambre MP; Bousquet-Gagnon N; Page M; Gingras D; Beliveau R
Centre de Cancerologie Charles-Bruneau, Hopital Ste-Justine et Universite du Quebec a Montreal, C.P. 8888, Succ. Centre-ville, H3C 3P8, Montreal, QC, Canada.

[(-)-Epigallocatechin gallate, the main constituent of Japanese green tea, inhibits tumor promotion of okadaic acid]
Fukuoka Igaku Zasshi 1996 Oct;87(10):215-21 Yoshizawa S
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.

Anti-metastatic activity of curcumin and catechin.
Cancer Lett 1999 Jul 1;141(1-2):159-65
Menon LG; Kuttan R; Kuttan G
Amala Cancer Research Centre, Trichur, India.

Retinoids and differentiation treatment: a strategy for treatment in cancer.
Anticancer Res 1994 Nov-Dec;14(6A):2339-46
Cornic M; Agadir A; Degos L; Chomienne C
Laboratoire de Biologie Cellulaire Hematopoietique, Hopital Saint-Louis, Paris, France.

P53 gene of chang-liver cells (Atcc-Ccl13) exposed to aflatoxin B1 (Afb): the effect of lysine on mutation at codon 249 of exon 7.
Afr J Med Med Sci. 1999 Mar-Jun;28(1-2):71-5.
Uwaifo O., Department of Biochemistry, University of Ibadan, Ibadan, Nigeria.

Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
Dermatologica. 1987;175(4):183-90
Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A.
Department of Medicine, Indiana University School of Medicine, Indianapolis.

Amino acid deficiency up-regulates specific mRNAs in murine embryonic cells.
J Nutr. 2002 Aug;132(8):2137-42
Fontanier-Razzaq N, Harries DN, Hay SM, Rees WD.
The Rowett Research Institute, Aberdeen, AB21 9SB Scotland, UK.

Identification and characterization of amino acid starvation-induced CD24 gene in MCF-7 human breast cancer cells.
Int J Oncol. 2000 May;16(5):1049-54
Liu W, Vadgama JV.
Department of Internal Medicine, Molecular Oncology Program, Charles R. Drew University of Medicine and Science, UCLA, School of Medicine, Los Angeles, CA 90059, USA.

Selenium effects on prostate cell growth.
Cancer Epidemiol Biomarkers Prev 2000 Nov;9(11):1171-82
Menter DG; Sabichi AL; Lippman SM
Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.