Induction of the placental form of glutathione S-transferase by lead nitrate administration in rat liver.

Toxicol Pathol 1987;15(2):202-5    

Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS

The administration of a single dose of lead nitrate to male Wistar rats caused an increase of a polypeptide in the liver cytosol that cross reacted with the anti- rat antibody of the placental form of glutathione S - transferase ( GST - P ). GST - P appeared when doses of lead that induced liver cell proliferation were given (5 and 10 micromoles/100 g of body weight). Recently, it has been shown that rat hepatic nodules also exhibited an increased content of the placental form of GST - P . The induction of GST - P by lead together with other biochemical effects exerted in the liver by this metal, suggests that some chemicals may induce in rat liver a biochemical pattern similar, in some aspects, to that exhibited by carcinogen-induced hepatocyte nodules.