A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models.

Biochem Biophys Res Commun 1983 Dec 28;117(3):740-5

Eriksson LC; Sharma RN; Roomi MW; Ho RK; Farber E; Murray RK

The cytosolic polypeptides of hepatocyte nodules in six models of liver carcinogenesis were analysed by SDS-polyacrylamide gel electrophoresis and their patterns compared with these of control and variously treated livers . The amount of a polypeptide of Mr 21,000 was about tenfold elevated in the cytosol of five of the six types of nodules and moderately elevated in the sixth. Certain other polypeptides , particularly one of Mr 26,000, also varied in amount, so that all of the nodules analysed could be distinguished from liver by their electrophoretic patterns . Some possible identities of the two polypeptides are discussed. Their study may have mechanistic as well as diagnostic importance.