The Scientific Breakthrough
Dr. Rath represents one of the great advances in
biological defence against cancer. His findings can be summarised
as follows:
- All types of cancer, irrespective of which
organ they start in, spread by the same means: they use biological
cutting tools (enzymes) that are capable of cutting through
the surrounding collagen connective tissue.
- The natural amino acid lysine, especially
in combination with vitamin C and other selected cellular
nutrients, is capable of blocking this 'collagen digestion'.
Thus we have a biological mechanism that can prevent the
spread of cancer cells - and therefore cancer itself.
- At Dr. Rath's Research Institute for Cellular
Medicine in Santa Clara, California, large-scale test sequences
have shown that all cancer types can be combated with the help
of this biological principle.
These research results have been presented at numerous
conferences of American and European cancer associations and
published in professional journals.
Scientific studies by
Dr. Rath and his Team
These research results have been presented
at numerous conferences of American and European cancer associations
and published in professional journals.
Effect Of Nutrient
Synergy on Human Osteosarcoma Cells U-2OS
M.Waheed Roomi, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki
A Specific
Combination Of Ascorbic Acid, Lysine, Proline And Epigallocatechin
Gallate Inhibits Proliferation And Extracellular Matrix Invasion
Of Various Human Cancer Cell Lines
Shrirang P Netke, M Waheed Roomi, Vadim Ivanov, Aleksandra Niedzwiecki* and
Matthias Rath
Matthias Rath, Inc., Research and Development, Santa Clara, CA 95054
Cytotxic
Effect of Lipophlic Substitution at 2-, 6-, and 2,6-Positions
in Ascorbic Acid and Expression of Matrix Metalloproteinases
in Hep G2 Cells, Melanoma Cells and Norman Human Dermal Fibroblast.
M.W. Roomi, S. Netke, V. Ivanov, A. Niedzwiecki and M. Rath
J. Am. Coll. Nutr. 20: 43, 2001
Inhibitory
effects of ascorbic acid, proline and lysine supplementation
on Matrigel invasion by human breast cancer cells, MDA-MB231.
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph.
D., Matthias Rath, M.D.
Presented at: 19th Annual Miami Breast Cancer Conference, Miami Beach, Florida,
February 27 - March 3, 2002. Published in: Conference Proceedings
Cellular
Medicine Research Breakthroughs in the Control of Diseases:
Report on Scientific Research
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph.
D., Matthias Rath, M.D.
Presented at: 21st Century Medical Advances in the Treatment of Cancer and
Aging, Miami , Fl, March 22-24, 2003; Published in: Conference Proceedings
Nutritional
supplement program halts progression of early coronary atherosclerosis.
M. Rath, M.D.
Controversies in Cardiovascular Nutrition, Stanford University Medical Center,
Stanford, CA, May 4, 2002
Metastatic
and Cytotoxic Effects of Ascorbigen and iso-Ascorbigen in Human
Cancer Cell Lines.
M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath
J. Am. Coll. Nut. 21: 54, 2002
Matrix
Metalloproteinase-2 Inhibition and Invasion Potential in Human
Chondrocytes by a natural anti-cancer formula - a Specific
Mixture of Nutrients Containing Lysine, Proline, Ascorbic Acid
and Epigallocatechin Gallate.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: American Association of Cancer Research Special Conference in
Cancer Research: Proteases, Extracellular Matrix and Cancer, Hilton Head Island,
South Carolina, Oct 9-13, 2002.
A
Natural Anti-Cancer Formula - A Specific Formulation of Nutrients
Containing Lysine,Proline, Ascorbic Acid, and Epigallocatechin
Gallate Inhibits Matrix Metalloproteinases Activity and Invasion
Potential of Human Cancer Cell Lines.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: European Organization for Research and Treatment of Cancer (EORTC),
AACR and NCI Symposium on Molecular Targets and Cancer Therapeutics, Frankfurt,
Germany, Nov 19-22, 2002; Published in: European Cancer Journal, 38, Suppl.7/Abs.280,
2002
Antitumorigenic
Activity of a Natural Anti-Cancer Formula in Human Breast Cancer
Lines MDA-MB-231 and MCF-7.
Roomi, M.W., Ivanov, V., Rath, M. and Niedzwiecki, A.
Presented at: The 8th Annual Multidisciplinary Symposium on Breast Disease,
Amelia Island, FL, February 13-16, 2003; Published in: Conference Proceedings
A
novel in vitro bioassay for screening matrix metalloproteinases
activity in human cancer cell lines
M Waheed Roomi, Shirang P Netke, Vadim Ivanov, Matthias Rath and Aleksandra
Niedzwiecki
Proceedings of the American Association for Cancer Research 44:4559(2003)
Inhibitory
Effect of a Natural Anti-Cancer Formula - A Specific Formulation
of Nutrients Containing Lysine, Proline, Ascorbic Acid and
Epigallocatechin Gallate on the Matrix Metalloproteinases Activities
and Invasion of Human Fibrosarcoma HT-1080 Cells
MW Roomi, V Ivanov, SP Netke, M Rath and A Niedzwiecki
FASEB Journal (2003) 8452
Aging
affects expression of 70-kDa heat shock proteins in Drosophila.
J Biol Chem 1991 May 15;266(14):9332-8
Niedzwiecki A; Kongpachith AM; Fleming JE
Expression
of bovine superoxide dismutase in Drosophila melanogaster augments
resistance of oxidative stress.
Mol Cell Biol 1991 Feb;11(2):632-40
Reveillaud I; Niedzwiecki A; Bensch KG; Fleming JE
Changes
in superoxide dismutase and catalase in aging heat-shocked
Drosophila.
Free Radic Res Commun 1992;17(6):355-67
Niedzwiecki A; Reveillaud I; Fleming JE
Role
of oxidative stress in Drosophila aging.
Mutat Res 1992 Sep;275(3-6):267-79
Fleming JE; Reveillaud I; Niedzwiecki A
Heat
shock induces changes in the expression and binding of ubiquitin
in senescent Drosophila melanogaster.
Dev Genet 1993;14(1):78-86
Niedzwiecki A; Fleming JE
Mechanistic
aspects of ascorbate inhibition of human immunodeficiency virus.
Chem Biol Interact 1994 Jun;91(2-3):207-15
Harakeh S; Niedzwiecki A; Jariwalla RJ
Ascorbate
affects proliferation of guinea-pig vascular smooth muscle
cells by direct and extracellular matrix-mediated effects.
J Mol Cell Cardiol 1997 Dec;29(12):3293-303
Ivanov VO; Ivanova SV; Niedzwiecki A
Transforming
growth factor-beta 1 and ascorbate regulate proliferation of
cultured smooth muscle cells by independent mechanisms.
Atherosclerosis 1998 Sep;140(1):25-34
Ivanov VO; Rabovsky AB; Ivanova SV; Niedzwiecki A
Porphyria-inducing
activity of a series of pyridine and dihydropyridine compounds.
Investigation in a cell culture system.
J Med Chem 1975 May;18(5):457-60
Roomi MW
The
action of trypsin on central and peripheral nerve myelin.
Adv Exp Med Biol 1978;100:307-28
Eylar EH; Roomi MW
The
PO protein. The major glycoprotein of peripheral nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):112-21
Roomi MW; Ishaque A; Khan NR; Eylar EH
Isolation
of a product from the trypsin-digested glycoprotein of sciatic
nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):122-33
Roomi MW; Eylar EH
The
PO glycoprotein of peripheral nerve myelin.
Can J Biochem 1980 Oct;58(10):913-21
Ishaque A; Roomi MW; Szymanska I; Kowalski S; Eylar EH
Effects
of phenobarbital upon triacylglycerol metabolism in the rabbit.
Biochem J 1980 Oct 15;192(1):165-75
Goldberg DM; Roomi MW; Yu A; Roncari DA
Effects
of phenobarbital upon triacylglycerol metabolism in the guinea
pig.
Can J Biochem 1981 Jan;59(1):48-53
Goldberg DM; Yu A; Roomi MW; Roncari DA
Enzyme
induction and hepatic glycerolipid synthesis in rats treated
with 3-methylcholanthrene.
Can J Biochem 1981 Sep;59(9):793-8
Goldberg DM; Roomi MW; Yu A; Roncari DA
Modulation
by phenobarbital of lipolytic activity in postheparin plasma
and tissues of the rat.
Can J Biochem 1982 Nov;60(11):1077-83
Goldberg DM; Roomi MW; Yu A
Age-related
changes in hepatic triacylglycerol content and phosphatidate
phosphohydrolase activities in fasting male and female rats.
Enzyme 1983;30(1):59-65
Goldberg DM; Roomi MW; Yu A
Growth
suppression of malignant leukemia cell line in vitro by ascorbic
acid (vitamin C) and its derivatives.
Cancer Lett 1998 Jan 9;122(1-2):93-9
Roomi MW; House D; Eckert-Maksic M; Maksic ZB; Tsao CS
Cytotoxic
effect of substitution at 2-, 6-, and 2,6-positions in ascorbic
acid on malignant cell line.
Cancer Biochem Biophys 1998 Nov;16(4):295-300
Roomi MW; House D; Tsao CS
Modulation
of drug metabolizing enzymes in guinea pig liver by high intakes
of ascorbic acid.
Int J Vitam Nutr Res 1998;68(1):42-7
Roomi MW; Netke S; Tsao C
Association
between hyperlipidemia and hepatic cytochrome P-450 in guinea
pigs.
Res Commun Mol Pathol Pharmacol 1997 Aug;97(2):139-50
Roomi MW
Changes
in drug-metabolizing enzymes of rats in ciprofibrate-induced
hepatic nodules.
Xenobiotica 1997 Sep;27(9):951-60
Roomi MW; Farber E; Parke DV
Ascorbic
acid deficiency decreases the expression of CYP4A1 in liver
microsomes of guinea pigs.
Res Commun Mol Pathol Pharmacol 1997 Jan;95(1):3-10
Roomi MW; Ogg M; Tsao CS; Gibson GG
Ascorbic
acid protects guinea pigs from acute aflatoxin toxicity.
Toxicol Appl Pharmacol 1997 Apr;143(2):429-35
Netke SP; Roomi MW; Tsao C; Niedzwiecki A
Modulation
of synovial fibroblast plasminogen activator and plasminogen
activator inhibitor production by protein kinase C.
Biochim Biophys Acta 1991 Nov 21;1097(4):283-8
Uhl J; Newton RC; Gross JL; Rommi W; Mochan E
Kinetics
of excretion of 2-acetylaminofluorene in normal and xenobiotic-treated
rats and in rats with hepatocyte nodules.
Lab Invest 1989 Mar;60(3):399-408
Rinaudo JA; Eriksson LC; Roomi MW; Farber E
Modulation
of the activity of hepatic gamma-glutamyl transpeptidase, adenosine
triphosphatase, placental glutathione S-transferase and adenylate
cyclase by acute administration of lead nitrate.
Basic Appl Histochem 1988;32(4):501-10
Columbano A; Ledda-Columbano GM; Ennas MG; Curto M; De Montis MG; Roomi MW;
Pani P; Sarma DS
Decreased
cytosolic levels of the heme binding Z protein in rat hepatocyte
nodules and hepatocellular carcinomas.
Cancer Lett 1988 Dec 1;43(1-2):55-8
Roomi MW; Vincent SH; Farber E; Muller-Eberhard U
The
galactosyltransferase activity of hepatic nodules during rat
liver carcinogenesis.
Cancer Lett 1988 Dec 1;43(1-2):49-54
Roomi MW; Mitranic MM; Farber E; Moscarello MA
Glutathione
and enzymes related to free radical metabolism in liver of
rats fed a choline-devoid low-methionine diet.
Cancer Lett 1988 Jul;41(1):53-62
Ghoshal A; Roomi MW; Ahluwalia M; Simmonds W; Rushmore TH; Farber E; Ghoshal
AK
Decreased
expression of cytochrome P-452 in the resistance phenotype
characteristic of putative preneoplastic hepatocyte nodules
during hepatocarcinogenesis.
Biochem Biophys Res Commun 1988 Apr 29;152(2):921-5
Roomi MW; Bacher MA; Gibson GG; Parke DV; Farber E
Induction
of the placental form of glutathione S-transferase by lead
nitrate administration in rat liver.
Toxicol Pathol 1987;15(2):202-5
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS
Identification
of a characteristic cytosolic polypeptide of rat preneoplastic
hepatocyte nodules as placental glutathione S-transferase.
Biochem Biophys Res Commun 1987 Feb 27;143(1):98-103
Rushmore TH; Sharma RN; Roomi MW; Harris L; Satoh K; Sato K; Murray RK; Farber
E
Lead
nitrate induces certain biochemical properties characteristic
of hepatocyte nodules.
Carcinogenesis 1986 Oct;7(10):1643-6
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS
Changes
in progesterone binding and metabolism in liver microsomes
from persistent hepatocyte nodules and hepatomas in male rats.
Cancer Res 1986 Jan;46(1):76-80
Feuer G; Stuhne-Sekalec L; Roomi MW; Cameron RG
Association
between progesterone binding and cytochrome P-450 content of
hepatic microsomes in the rat treated with cobalt-haem.
Xenobiotica 1985 May;15(5):407-12
Feuer G; Waheed Roomi M; Stuhne-Sekalec L; Cameron RG
A
common biochemical pattern in preneoplastic hepatocyte nodules
generated in four different models in the rat.
Cancer Res 1985 Feb;45(2):564-71
Roomi MW; Ho RK; Sarma DS; Farber E
Chemical
carcinogenesis: hepatocyte nodules with a special phenotype
as a common step at the crossroads.
Toxicol Pathol 1984;12(3):288-90
Farber E; Eriksson LC; Roomi MW; Cameron RG; Hayes MA
Comparative
influences of different PB-type and 3-MC-type polychlorinated
biphenyl-induced phenotypes on cytocidal hepatotoxicity of
bromobenzene and acetaminophen.
Toxicol Appl Pharmacol 1984 Oct;76(1):118-27
H ayes MA; Roberts E; Roomi MW; Safe SH; Farber E; Cameron RG
Orotic
acid, a new promoter for experimental liver carcinogenesis.
Toxicol Pathol 1984;12(2):173-8
Rao PM; Nagamine Y; Roomi MW; Rajalakshmi S; Sarma DS
A
characteristic electrophoretic pattern of cytosolic polypeptides
from hepatocyte nodules generated during liver carcinogenesis
in several models.
Biochem Biophys Res Commun 1983 Dec 28;117(3):740-5
Eriksson LC; Sharma RN; Roomi MW; Ho RK; Farber E; Murray RK
